Neuroprotective effects of curcumin on the cerebellum in a rotenone-induced Parkinson's Disease Model.

ABSTRACT:

Aims

Parkinson's disease (PD) is the second most prevalent age-related neurodegenerative disorder. The cerebellum plays a role in PD pathogenesis. Curcumin has numerous medicinal uses, mostly attributed to its potent antioxidant properties. This study investigated the potential protective influence of curcumin on the cerebellum of albino rats with rotenone-induced PD.

Methods

Forty adult male albino rats were randomized into four treatment groups: vehicle (group I); rotenone 3 mg/kg/day i.p. injection (group II); rotenone 3 mg/kg/day plus curcumin 30 mg/kg/day i.p. injection (group III); and curcumin 30 mg/kg/day i.p. injection (group IV).

Results

Compared to group I, group II exhibited marked degenerative changes in hematoxylin & eosin-stained sections and a reductio

SUBMITTER: Fikry H 

PROVIDER: S-EPMC8981438 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature