Loss of cardiac myosin light chain kinase contributes to contractile dysfunction in right ventricular pressure overload.

ABSTRACT: Nearly 1 in every 100 children born have a congenital heart defect. Many of these defects primarily affect the right heart causing pressure overload of the right ventricle (RV). The RV maintains function by adapting to the increased pressure; however, many of these adaptations eventually lead to RV hypertrophy and failure. In this study, we aim to identify the cellular and molecular mechanisms of these adaptions. We utilized a surgical animal model of pulmonary artery banding (PAB) in juvenile rats that has been shown to accurately recapitulate the physiology of right ventricular pressure overload in young hearts. Using this model, we examined changes in cardiac myocyte protein expression as a result of pressure overload with mass spectrometry 4 weeks post-banding. We found pressure overlo

SUBMITTER: Prasad V 

PROVIDER: S-EPMC8981447 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature