Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis.

ABSTRACT: Obesity and poor diet often go hand-in-hand, altering metabolic signaling and thereby impacting breast cancer risk and outcomes. We have recently demonstrated that dietary patterns modulate mammary microbiota populations. An important and largely open question is whether the microbiome of the gut and mammary gland mediates the dietary effects on breast cancer. To address this, we performed fecal transplants between mice on control or high-fat diets (HFD) and recorded mammary tumor outcomes in a chemical carcinogenesis model. HFD induced protumorigenic effects, which could be mimicked in animals fed a control diet by transplanting HFD-derived microbiota. Fecal transplants altered both the gut and mammary tumor microbiota populations, suggesting a link between the gut and breast microbiomes.

SUBMITTER: Soto-Pantoja DR 

PROVIDER: S-EPMC8981494 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature