Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process.

ABSTRACT: A curcumin derivative conjugated with Gd-DO3A (Gd-DO3A-Comp.B) was synthesised as an MRI contrast agent for detecting the amyloid-β (Aβ) fibrillation process. Gd-DO3A-Comp.B inhibited Aβ aggregation significantly and detected the fibril growth at 20 μM of Aβ with 10 μM of probe concentration by T ₁-weighted MR imaging.

SUBMITTER: Utomo RY 

PROVIDER: S-EPMC8981495 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature