Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process.
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ABSTRACT:
SUBMITTER: Utomo RY
PROVIDER: S-EPMC8981495 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process.
Utomo Rohmad Yudi RY Okada Satoshi S Sumiyoshi Akira A Aoki Ichio I Nakamura Hiroyuki H
RSC advances 20220209 8
A curcumin derivative conjugated with Gd-DO3A (Gd-DO3A-Comp.B) was synthesised as an MRI contrast agent for detecting the amyloid-β (Aβ) fibrillation process. Gd-DO3A-Comp.B inhibited Aβ aggregation significantly and detected the fibril growth at 20 μM of Aβ with 10 μM of probe concentration by <i>T</i> <sub>1</sub>-weighted MR imaging. ...[more]
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