Gut microbiota is causally associated with poststroke cognitive impairment through lipopolysaccharide and butyrate.

ABSTRACT:

Background

Poststroke cognitive impairment (PSCI) is prevalent in stroke patients. The etiology of PSCI remains largely unknown. We previously found that stroke induces gut microbiota dysbiosis which affects brain injury. Hereby, we aimed to investigate whether the gut microbiota contributes to the pathogenesis of PSCI.

Methods

83 stroke patients were recruited and their cognitive function were measured by Montreal Cognitive Assessment (MoCA) scores 3 months after stroke onset. The peripheral inflammatory factor levels and gut microbiota compositions of the patients were analyzed. Fecal microbiota transplantation from patients to stroke mice was performed to examine the causal relationship between the gut microbiota and PSCI. The cognitive function of mice was evaluated by M

SUBMITTER: Wang H 

PROVIDER: S-EPMC8981610 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature