Association between the type of thyroid dysfunction induced by immune checkpoint inhibitors and prognosis in cancer patients.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs) cause thyroid immune-related adverse effects (irAEs). However, associations between each type of thyroid immune-related adverse effect (irAE) and the anti-tumor effect of ICI remains unknown. This study aimed to determine the effects of each type of thyroid dysfunction on patient survival.

Methods

Patients who initiated ICI treatment from January 2015 to December 2019 in Seoul St. Mary's Hospital were retrospectively analyzed. Thyroid dysfunction was classified into four types: newly developed overt or subclinical hypothyroidism, thyrotoxicosis, worsened hypothyroidism, and subclinical hyperthyroidism. Patients were divided into two groups according to the presence or absence of thyroid dysfunction.

Results

Among the 191

SUBMITTER: Baek HS 

PROVIDER: S-EPMC8981627 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature