CTCF in parvalbumin-expressing neurons regulates motor, anxiety and social behavior and neuronal identity.

ABSTRACT: CCCTC-binding factor (CTCF) is a regulator of chromatin organization and has direct effects on gene transcription. Mutations in CTCF have been identified in individuals with neurodevelopmental conditions. There are wide range of behaviors associated with these mutations, including intellectual disabilities, changes in temperament, and autism. Previous mice-model studies have identified roles for CTCF in excitatory neurons in specific behaviors, particularly in regards to learning and memory. However, the role of CTCF in inhibitory neurons is less well defined. In the current study, specific knockout of CTCF in parvalbumin-expressing neurons, a subset of inhibitory neurons, induced a specific behavioral phenotype, including locomotor abnormalities, anxiolytic behavior, and a decrease in soc

SUBMITTER: Davis L 

PROVIDER: S-EPMC8981645 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature