A new risk model based on a 11-m⁶A-related lncRNA signature for predicting prognosis and monitoring immunotherapy for gastric cancer.

ABSTRACT:

Objective

N⁶-methyladenosine (m⁶A) mRNA modification triggers malignant behaviors of tumor cells and thereby drives malignant progression in gastric cancer (GC). However, data regarding the prognostic values of m⁶A RNA methylation-related long non-coding RNAs (lncRNAs) in GC are very limited in the literature. We aimed to investigate the prognostic potential of m⁶A-related lncRNAs in predicting prognosis and monitoring immunotherapy efficacy in GC patients.

Methods

Transcriptome and clinical data were obtained from GC biopsies from Cancer Genome Atlas (TCGA). M⁶A-related lncRNAs associated with GC were identified by constructing a co-expression network, and the gene pairs differentially expressed in GC were selected usin

SUBMITTER: Lei L 

PROVIDER: S-EPMC8981748 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature