L-Cysteine modified metal-organic framework as a chiral stationary phase for enantioseparation by capillary electrochromatography.

ABSTRACT: A new kind of chiral zirconium based metal-organic framework, l-Cys-PCN-222, was synthesized using l-cysteine (l-Cys) as a chiral modifier by a solvent-assisted ligand incorporation approach and utilized as the chiral stationary phase in the capillary electrochromatography system. l-Cys-PCN-222 was characterized by X-ray diffraction, thermogravimetric analysis, X-ray photoelectron spectroscopy, Fourier-transform infrared spectra, nitrogen adsorption/desorption, circular dichroism spectrum, zeta-potential and so on. The results revealed that l-Cys-PCN-222 had the advantages of good crystallinity, high specific surface area (1818 m² g^-1), thermal stability and chiral recognition performance. Meanwhile, the l-Cys-PCN-222-bonded open-tubular column was prepared using l-Cy

SUBMITTER: Lidi G 

PROVIDER: S-EPMC8981955 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature