Identification and functional validation of HLA-C as a potential gene involved in colorectal cancer in the Korean population.

ABSTRACT:

Background

Colorectal cancer (CRC) is the third most common cancer worldwide and is influenced by environmental and genetic factors. Although numerous genetic loci for CRC have been identified, the overall understanding of the genetic factors is yet to be elucidated. We sought to discover new genes involved in CRC applying genetic association analysis and functional study.

Results

We conducted exome array analysis on 194 CRC and 600 control subjects for discovering new candidate CRC genes. Fisher's exact test detected one exome-wide significant functional locus for CRC on SMCO1 (P < 10^-6) and two suggestive functional loci on HLA-C and NUTM1 (10^-6 ≤ P < 10^-4). To evaluate the biological role of three candidate CRC genes, the differential expr

SUBMITTER: Lim EB 

PROVIDER: S-EPMC8981957 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature