Secondary infection with <i>Streptococcus pneumoniae</i> decreases influenza virus replication and is linked to severe disease.

ABSTRACT: Secondary bacterial infection is a common complication in severe influenza virus infections. During the H1N1 pandemic of 2009, increased mortality was observed among healthy young adults due to secondary bacterial pneumonia, one of the most frequent bacterial species being Streptococcus pneumoniae (Spn). Previous studies in mice and ferrets have suggested a synergistic relationship between Spn and influenza viruses. In this study, the ferret model was used to examine whether secondary Spn infection (strains BHN97 and D39) influence replication and airborne transmission of the 2009 pandemic H1N1 virus (H1N1pdm09). Secondary infection with Spn after H1N1pdm09 infection consistently resulted in a significant decrease in viral titers in the ferret nasal washes. While secondary Spn infec

SUBMITTER: Mueller Brown K 

PROVIDER: S-EPMC8981988 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature