Prognostic value of O ⁶-methylguanine-DNA methyltransferase methylation in isocitrate dehydrogenase mutant gliomas.

ABSTRACT:

Background

Patients with isocitrate dehydrogenase (IDH) mutant gliomas have been associated with longer survival time than those that are IDH wild-type. Previous studies have shown the prognostic value of O ⁶ -methylguanine-DNA methyltransferase (MGMT) promoter methylation for glioblastoma multiforme (GBM), which are predominantly IDH wild-type. Little is known of the prognostic value of MGMT methylation status for IDH mutant gliomas.

Methods

We retrospectively identified IDH mutant gliomas patients between 2011 and 2020 that were tested for MGMT promoter methylation. We generated Kaplan-Meier estimator curves and performed Cox proportional hazard models for overall survival (OS) a

SUBMITTER: Lam K 

PROVIDER: S-EPMC8982195 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature