Management of brain metastasis. Surgical resection versus stereotactic radiotherapy: a meta-analysis.

ABSTRACT:

Background

Treatment of metastatic brain tumors often involves radiotherapy with or without surgical resection as the first step. However, the indications for when to use surgery are not clearly defined for certain tumor sizes and multiplicity. This study seeks to determine whether resection of brain metastases versus exclusive radiotherapy provided improved survival and local control in cases where metastases are limited in number and diameter.

Methods

According to PRISMA guidelines, this meta-analysis compares outcomes from treatment of a median number of brain metastases ≤ 4 with a median diameter ≤ 4 cm with exclusive radiotherapy versus surgery followed by radiotherapy. Four randomized control trials and 11 observational studies (1693 patients) met inclusion criteria. F

SUBMITTER: Krist DT 

PROVIDER: S-EPMC8982204 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature