Preclinical evaluation of drug treatment options for sleep-related epileptiform spiking in Alzheimer's disease.

ABSTRACT:

Introduction

There are no published data on prospective clinical studies on drug treatment options for sleep-related epileptiform spiking in Alzheimer's disease (AD).

Methods

Using video-EEG with hippocampal electrodes in 17 APP/PS1 transgenic male mice we assessed the effects of donepezil and memantine, anti-seizure drugs levetiracetam and lamotrigine, gamma-secretase inhibitor semagacestat, anti-inflammatory minocycline and adenosine receptor antagonist istradephylline on density of cortical and hippocampal spikes during sleep.

Results

Levetiracetam decreased the density of hippocampal giant spikes and cortical spikes. Lamotrigine reduced cortical single spikes and spike-wave discharges but dramatically increased hippocampal giant spikes. Memantine increased cortica

SUBMITTER: Jin N 

PROVIDER: S-EPMC8982322 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature