Prediagnostic Serum Vitamin D, Vitamin D Binding Protein Isoforms, and Cancer Survival.

ABSTRACT:

Background

Higher circulating vitamin D has been associated with improved overall cancer survival, but data for organ-specific cancers are mixed.

Methods

We examined the association between prediagnostic serum 25-hydroxyvitamin D [25(OH)D], the recognized biomarker of vitamin D status, and cancer survival in 4038 men and women diagnosed with 1 of 11 malignancies during 22 years of follow-up (median = 15.6 years) within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Multivariable-adjusted proportional hazards regression estimated hazard ratios (HR) and 95% confidence intervals (CI) for associations between baseline 25(OH)D concentration and subsequent cancer survival; we also stratified on the common vitamin D binding protein isoforms (Gc1f, Gc1s, and Gc2

SUBMITTER: Weinstein SJ 

PROVIDER: S-EPMC8982405 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature