OBIF: an omics-based interaction framework to reveal molecular drivers of synergy.

ABSTRACT: Bioactive molecule library screening may empirically identify effective combination therapies, but molecular mechanisms underlying favorable drug-drug interactions often remain unclear, precluding further rational design. In the absence of an accepted systems theory to interrogate synergistic responses, we introduce Omics-Based Interaction Framework (OBIF) to reveal molecular drivers of synergy through integration of statistical and biological interactions in synergistic biological responses. OBIF performs full factorial analysis of feature expression data from single versus dual exposures to identify molecular clusters that reveal synergy-mediating pathways, functions and regulators. As a practical demonstration, OBIF analyzed transcriptomic and proteomic data of a dyad of immunostimulato

SUBMITTER: Pantaleon Garcia J 

PROVIDER: S-EPMC8982434 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature