Prospective study of oral microbiome and gastric cancer risk among Asian, African American and European American populations.

ABSTRACT: Colonization of specific bacteria in the human mouth was reported to be associated with gastric cancer risk. However, previous studies were limited by retrospective study designs and low taxonomic resolutions. We performed a prospective case-control study nested within three cohorts to investigate the relationship between oral microbiome and gastric cancer risk. Shotgun metagenomic sequencing was employed to characterize the microbiome in prediagnostic buccal samples from 165 cases and 323 matched controls. Associations of overall microbial richness and abundance of microbial taxa, gene families and metabolic pathways with gastric cancer risk were evaluated via conditional logistic regression. Analyses were performed within each cohort, and results were combined by meta-analyses. We found

SUBMITTER: Yang Y 

PROVIDER: S-EPMC8982516 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature