Identification and characteristic analysis of enhancers across 13 major cancer types.
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ABSTRACT:
SUBMITTER: Qian M
PROVIDER: S-EPMC8982554 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Identification and characteristic analysis of enhancers across 13 major cancer types.
Qian Mingming M Wang Wenzhu W Zhang Yana Y Zhao Yi Y Quan Huige H Chen Yuting Y Dai Xinyue X Guo Zhiyun Z
Precision clinical medicine 20210802 3
Enhancers are often mutated and dysregulated in various diseases such as cancer. By integrating the function annotation of the mammalian genome (FANTOM) enhancers expression profiles and RNA-seq data from The Cancer Genome Atlas (TCGA) of 13 cancers and their corresponding <i>para</i>-cancerous tissues, we systematically identified a total of 4702 significantly differentially expressed (DE) enhancers. Furthermore, a total of 1036 DE genes regulated by DE enhancers were identified. It was found t ...[more]
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