Ontology highlight
ABSTRACT:
SUBMITTER: Wyart E
PROVIDER: S-EPMC8982578 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Wyart Elisabeth E Hsu Myriam Y MY Sartori Roberta R Mina Erica E Rausch Valentina V Pierobon Elisa S ES Mezzanotte Mariarosa M Pezzini Camilla C Bindels Laure B LB Lauria Andrea A Penna Fabio F Hirsch Emilio E Martini Miriam M Mazzone Massimiliano M Roetto Antonella A Geninatti Crich Simonetta S Prenen Hans H Sandri Marco M Menga Alessio A Porporato Paolo E PE
EMBO reports 20220224 4
Cachexia is a wasting syndrome characterized by devastating skeletal muscle atrophy that dramatically increases mortality in various diseases, most notably in cancer patients with a penetrance of up to 80%. Knowledge regarding the mechanism of cancer-induced cachexia remains very scarce, making cachexia an unmet medical need. In this study, we discovered strong alterations of iron metabolism in the skeletal muscle of both cancer patients and tumor-bearing mice, characterized by decreased iron av ...[more]