Ontology highlight
ABSTRACT:
SUBMITTER: Goswami I
PROVIDER: S-EPMC8982582 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Goswami Imon I Sandlesh Poorva P Stablewski Aimee A Toshkov Ilya I Safina Alfiya F AF Magnitov Mikhail M Wang Jianmin J Gurova Katerina K
EMBO reports 20220218 4
Preservation of nucleosomes during replication has been extensively studied, while the maintenance of nucleosomes during transcription has gotten less attention. The histone chaperone FACT has a role in transcription elongation, although whether it disassembles or assembles nucleosomes during this process is unclear. To elucidate the function of FACT in mammals, we deleted the Ssrp1 subunit of FACT in adult mice. FACT loss is lethal, possibly due to the loss of the earliest progenitors in bone m ...[more]