Epigenetic inheritance is gated by naive pluripotency and Dppa2.

ABSTRACT: Environmental factors can trigger cellular responses that propagate across mitosis or even generations. Perturbations to the epigenome could underpin such acquired changes, however, the extent and contexts in which modified chromatin states confer heritable memory in mammals is unclear. Here, we exploit a precision epigenetic editing strategy and forced Xist activity to programme de novo heterochromatin domains (epialleles) at endogenous loci and track their inheritance in a developmental model. We find that naïve pluripotent phases systematically erase ectopic domains of heterochromatin via active mechanisms, which likely acts as an intergenerational safeguard against transmission of epialleles. Upon lineage specification, however, acquired chromatin states can be probabilistically inheri

SUBMITTER: Carlini V 

PROVIDER: S-EPMC8982627 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature