Neurologic outcome of VZV encephalitis one year after ICU admission: a multicenter cohort study.

ABSTRACT:

Background

Varicella-zoster virus (VZV) is one of the main viruses responsible of acute encephalitis. However, data on the prognosis and neurologic outcome of critically ill patients with VZV encephalitis are limited. We aimed to describe the clinical features of VZV encephalitis in the ICU and to identify factors associated with a favorable neurologic outcome. We performed a multicenter cohort study of patients with VZV encephalitis admitted in 18 ICUs in France between 2000 and 2017. Factors associated with a favorable neurologic outcome, defined by a modified Rankin Score (mRS) of 0-2 1 year after ICU admission, were identified by multivariable regression analysis.

Results

Fifty-five patients (29 (53%) men, median age 53 (interquartile range 36-66)) were included, of whom

SUBMITTER: Mirouse A 

PROVIDER: S-EPMC8982685 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature