Reproductive factors and the risk of incident dementia: A cohort study of UK Biobank participants.

ABSTRACT:

Background

Women's reproductive factors have been associated with the risk of dementia; however, these findings remain uncertain. This study aimed to examine the risk of incident all-cause dementia associated with reproductive factors in women and the number of children in both sexes and whether the associations vary by age, socioeconomic status (SES), smoking status, and body mass index (BMI) in the UK Biobank.

Methods and findings

A total of 273,240 women and 228,957 men without prevalent dementia from the UK Biobank were included in the analyses. Cox proportional hazard regressions estimated hazard ratios (HRs) for reproductive factors with incident all-cause dementia. Multiple adjusted models included age at study entry, SES, ethnicity, smoking status, systolic blood pre

SUBMITTER: Gong J 

PROVIDER: S-EPMC8982865 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature