Circulating ADAMTS13 Levels Are Associated with an Increased Occurrence of Obstructive Sleep Apnea.

ABSTRACT:

Background and aims

Obstructive sleep apnea (OSA) is strongly associated with obesity, metabolic diseases, coronary artery disease (CAD), stroke, hypertension, and other disorders. This study assessed the relationship between circulating a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13 (ADAMTS13) levels and the presence of OSA.

Materials and methods

This cross-sectional study included a total of 223 patients. We used a powerful high-throughput multiplexed immunobead-based assay to detect circulating levels of ADAMTS13. The associations between circulating ADAMTS13 levels and OSA were evaluated by multivariate logistic regression analysis.

Results

Circulating ADAMTS13 levels were significantly elevated in patients with OSA compared with c

SUBMITTER: Huang M 

PROVIDER: S-EPMC8983172 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature