Ontology highlight
ABSTRACT:
SUBMITTER: Lian BSX
PROVIDER: S-EPMC8983349 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Lian Benedict Shi Xiang BSX Kawasaki Takumi T Kano Norisuke N Ori Daisuke D Ikegawa Moe M Isotani Ayako A Kawai Taro T
iScience 20220318 4
The innate immune system is an immediate defense against infectious pathogens by the production of inflammatory cytokines and other mediators. Deficiencies of epigenetic regulatory enzymes, such as <i>Tet1</i> and <i>Dnmt1</i>, cause dysregulation of cytokine expression. However, it is unclear if DNA methylation at a single CpG dinucleotide in a specific gene locus can regulate gene expression. In this study, we demonstrated that CpG+286 and CpG+348 in exon 2 of the <i>Il6</i> gene are similar i ...[more]