Intensive single-cell analysis reveals immune-cell diversity among healthy individuals.

ABSTRACT: Immune responses are different between individuals and personal health histories and unique environmental conditions should collectively determine the present state of immune cells. However, the molecular systems underlying such heterogeneity remain elusive. Here, we conducted a systematic time-lapse single-cell analysis, using 171 single-cell libraries and 30 mass cytometry datasets intensively for seven healthy individuals. We found substantial diversity in immune-cell profiles between different individuals. These patterns showed daily fluctuations even within the same individual. Similar diversities were also observed for the T-cell and B-cell receptor repertoires. Detailed immune-cell profiles at healthy statuses should give essential background information to understand their immune r

SUBMITTER: Kashima Y 

PROVIDER: S-EPMC8983398 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature