Risk of herpesvirus, serious and opportunistic infections in atopic dermatitis: a population-based cohort study.

ABSTRACT:

Background

Staphylococcal and herpes simplex virus (HSV) infections are commonly recognized in atopic dermatitis (AD), but less is known about other types of infections.

Objectives

To determine the risk of herpesvirus infections, serious infections and opportunistic infections in patients with AD.

Methods

We conducted a population-based cohort study using UK-based electronic medical records data. Patients with AD were each matched to up to five unaffected patients on age, practice and index date. AD severity was defined using treatments as a proxy. Outcomes were incident herpesvirus infections [cytomegalovirus (CMV), Epstein-Barr virus (EBV), HSV or varicella zoster virus (VZV)], serious infections and opportunistic infections.

Results

Among 409 431 children an

SUBMITTER: Wan J 

PROVIDER: S-EPMC8983460 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature