A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation.

ABSTRACT: The RAS GTPases are frequently mutated in human cancer, with KRAS being the predominant tumor driver. For many years, it has been known that the structure and function of RAS are integrally linked, as structural changes induced by GTP binding or mutational events determine the ability of RAS to interact with regulators and effectors. Recently, a wealth of information has emerged from structures of specific KRAS mutants and from structures of multiprotein complexes containing RAS and/or RAF, an essential effector of RAS. These structures provide key insights regarding RAS and RAF regulation as well as promising new strategies for therapeutic intervention.

Significance

The RAS GTPases are major drivers of tumorigenesis, and for RAS proteins to exert their full oncogenic potential, the

SUBMITTER: Simanshu DK 

PROVIDER: S-EPMC8983508 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature