Genetic Analysis in African American Children Supports Ancestry-Specific Neuroblastoma Susceptibility.

ABSTRACT:

Background

Neuroblastoma is rarer in African American (AA) children compared with American children of European descent. AA children affected with neuroblastoma, however, more frequently develop the high-risk form of the disease.

Methods

We have genotyped an AA cohort of 629 neuroblastoma cases (254 high-risk) and 2,990 controls to investigate genetic susceptibility to neuroblastoma in AAs.

Results

We confirmed the known neuroblastoma susceptibility gene BARD1 at genome-wide significance in the subset of high-risk cases. We also estimated local admixture across the autosomal genome in the AA cases and controls and detected a signal at 4q31.22 where cases show an increase in European ancestry. A region at 17p13.1 showed increased African ancestry in the subgroup of hig

SUBMITTER: Testori A 

PROVIDER: S-EPMC8983590 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature