Combining adoptive NK cell infusion with a dopamine-releasing peptide reduces senescent cells in aged mice.

ABSTRACT: Aging inducing the development of senescent cells (SNCs) in various tissues is considered as the main cause of the age-related diseases. Senotherapy has become a promising anti-aging therapy. However, the effectivity and side-effect of senolytic agents are still concern. Here, we observed the downregulation of senescence-related genes by adoptive infusion of natural killer (NK) cells in 26 cases in peripheral blood CD3⁺ T cells. NK cell treatment also significantly decreased levels of senescence markers and senescence-associated secretory phenotypes (SASPs) in three senescent adipose tissues when culturing them together. Interestingly, cytotoxic activity of mouse NK cells against SNCs was significantly enhanced by dopamine in vitro through D1-like receptors. Acein, dopamine-rele

SUBMITTER: Bai Z 

PROVIDER: S-EPMC8983684 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature