Improvement of episodic memory retention by a memory reactivation intervention across the lifespan: from younger adults to amnesic patients.

ABSTRACT: Spontaneous reactivation of recently acquired memories is a fundamental mechanism of memory stabilization. Re-exposure to specific learned cues during sleep or awake states, namely targeted memory reactivation, has been shown to improve memory retention at long delays. Manipulation of memory reactivation could have potential clinical value in populations with memory deficits or cognitive decline. However, no previous study investigated a target memory reactivation approach on those populations. Here we tested the hypothesis that a reactivation-based intervention would improve episodic memory performance in healthy adults and amnestic patients. On Day 1, young adults, old adults and amnestic Mild Cognitive Impairment patients (n = 150) learned face-name pairs and 24 h later either received

SUBMITTER: Fernandez RS 

PROVIDER: S-EPMC8983690 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature