Structural validation and assessment of AlphaFold2 predictions for centrosomal and centriolar proteins and their complexes.

ABSTRACT: Obtaining the high-resolution structures of proteins and their complexes is a crucial aspect of understanding the mechanisms of life. Experimental structure determination methods are time-consuming, expensive and cannot keep pace with the growing number of protein sequences available through genomic DNA sequencing. Thus, the ability to accurately predict the structure of proteins from their sequence is a holy grail of structural and computational biology that would remove a bottleneck in our efforts to understand as well as rationally engineer living systems. Recent advances in protein structure prediction, in particular the breakthrough with the AI-based tool AlphaFold2 (AF2), hold promise for achieving this goal, but the practical utility of AF2 remains to be explored. Focusing on protei

SUBMITTER: van Breugel M 

PROVIDER: S-EPMC8983713 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature