Novel and extendable genotyping system for human respiratory syncytial virus based on whole-genome sequence analysis.

ABSTRACT:

Background

Human respiratory syncytial virus (RSV) is one of the leading causes of respiratory infections, especially in infants and young children. Previous RSV sequencing studies have primarily focused on partial sequencing of G gene (200-300 nucleotides) for genotype characterization or diagnostics. However, the genotype assignment with G gene has not recapitulated the phylogenetic signal of other genes, and there is no consensus on RSV genotype definition.

Methods

We conducted maximum likelihood phylogenetic analysis with 10 RSV individual genes and whole-genome sequence (WGS) that are published in GenBank. RSV genotypes were determined by using phylogenetic analysis and pair-wise node distances.

Results

In this study, we first statistically examined the phylogene

SUBMITTER: Chen J 

PROVIDER: S-EPMC8983899 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature