Genotypes of Pain and Analgesia in a Randomized Trial of Irritable Bowel Syndrome.

ABSTRACT:

Background

Irritable bowel syndrome (IBS) is a highly prevalent chronic pain disorder with multiple underlying mechanisms and few treatments that have been demonstrated to be effective in placebo controlled trials. One potential reason may be the use of composite outcomes, such as the IBS Symptom Severity Scale (IBS-SSS) which includes descriptive items related to pain frequency and pain intensity as well as bowel dysfunction and bloating. We investigated if different features of IBS pain have distinct genetic associations and if these may be moderated by sex hormones.

Participants and setting

Adult outpatients with moderately severe IBS (>175 on IBS-SSS) enrolled in a clinical trial reported IBS-SSS at baseline and after 6 weeks of therapy.

Methods

Fixed effects mode

SUBMITTER: Vollert J 

PROVIDER: S-EPMC8983929 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature