Elevated METTL9 is associated with peritoneal dissemination in human scirrhous gastric cancers.

ABSTRACT: Methylation, the most common chemical modification of cellular components such as DNA, RNA, and proteins, impacts biological processes including transcription, RNA processing, and protein dynamics. Although abnormal expression of methyltransferase can lead to various diseases including cancers, little is known about the relationship between methyltransferase and cancers. Here we aimed to understand the role of methyltransferase in cancer metastasis. We found that elevated methyltransferase-like 9 (METTL9) is closely associated with the acquisition of metastatic activity in human scirrhous gastric cancers. The stable knockdown of METTL9 via an shRNA vector technique in our original metastatic cells from scirrhous gastric cancer patients significantly inhibited migration and invasion. In met

SUBMITTER: Hara T 

PROVIDER: S-EPMC8983939 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature