Cell Type-Specific Transcriptional Control of Gsk3β in the Developing Mammalian Neocortex.

ABSTRACT: Temporal control of neurogenesis is central for the development and evolution of species-specific brain architectures. The balance between progenitor expansion and neuronal differentiation is tightly coordinated by cell-intrinsic and cell-extrinsic cues. Wnt signaling plays pivotal roles in the proliferation and differentiation of neural progenitors in a temporal manner. However, regulatory mechanisms that adjust intracellular signaling amplitudes according to cell fate progression remain to be elucidated. Here, we report the transcriptional controls of Gsk3β, a critical regulator of Wnt signaling, in the developing mouse neocortex. Gsk3β expression was higher in ventricular neural progenitors, while it gradually declined in differentiated neurons. We identified active cis

SUBMITTER: Nomura T 

PROVIDER: S-EPMC8983961 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature