The Temporal Modulation of Nocebo Hyperalgesia in a Model of Sustained Pain.

ABSTRACT:

Background

The direction and the magnitude of verbal suggestions have been shown to be strong modulators of nocebo hyperalgesia, while little attention has been given to the role of their temporal content. Here, we investigate whether temporal suggestions modulate the timing of nocebo hyperalgesia in an experimental model of sustained pain.

Methods

Fifty-one healthy participants were allocated to one of three groups. Participants received an inert cream and were instructed that the agent had either hyperalgesic properties setting in after 5 (Nocebo 5, N5) or 30 (Nocebo 30, N30) minutes from cream application, or hydrating properties (No Expectation Group, NE). Pain was induced by the Cold Pressure Test (CPT) which was repeated before cream application (baseline) and after 10

SUBMITTER: Camerone EM 

PROVIDER: S-EPMC8983965 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature