Structural study of bioisosteric derivatives of 5-(1H-indol-3-yl)-benzotriazole and their ability to form chalcogen bonds.

ABSTRACT: Recently, inter-est in the isosteric replacement of a nitro-gen atom to selenium, sulfur or oxygen atoms has been highlighted in the design of potential inhibitors for cancer research. In this context, the structures of 5-(1H-indol-3-yl)-2,1,3-benzotriazole derivatives [5-(1H-indol-3-yl)-2,1,3-benzo-thia-diazole (bS, C₁₄H₉N₃S) and 5-(1H-indol-3-yl)-2,1,3-benzoxa-diazole (bO, C₁₄H₉N₃O)], as well as a synthesis inter-mediate of the selenated bioisostere [5-[1-(benzensulfon-yl)-1H-indol-3-yl]-2,1,3-benzoselena-diazole (p-bSe, C₂₀H₁₃N₃O₂SSe)] were determined using single-crystal X-ray diffraction (SCXRD) analyses. Despite being analogues, different crystal p

SUBMITTER: Mirgaux M 

PROVIDER: S-EPMC8983978 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature