Dataset Information

Gastric Cancer in Older Patients: A Retrospective Study and Literature Review.

ABSTRACT:

Background

With increasing life expectancy, the incidence of gastric cancer (GC) in older adults is increasing. This study analyzed differences in GC characteristics according to age and sex among patients who underwent surgical treatment for GC.

Methods

A total of 2,983 patients diagnosed with gastric adenocarcinoma who underwent surgical treatment at Seoul National University Bundang Hospital between 2003 and 2017 were classified into three groups: I (<65 years, n=1,680), II (60-74 years, n=919), and III (≥75 years, n=384). We compared the baseline clinical characteristics, pathological characteristics of the tumor, overall and GC-specific survival rates, and associated risk factors between the groups.

Results

Cancer of the distal third of the stomach (p<0.001), with intestinal-type histology (p<0.001), and with p53 overexpression (p=0.004) were more common in groups II and III than in group I, and the proportion of intestinal-type GC increased with age. The cancer type, lymph node metastasis, and cancer stage did not differ significantly. In terms of overall survival, survival decreased with increasing age (p<0.001), but this difference decreased significantly for GC-specific survival. Cox multivariate analyses revealed age, histologic type (diffuse or mixed type), and advanced cancer stage (p=0.002, 0.001, and <0.001, respectively) as risk factors for GC-related mortality.

Conclusion

Age itself was found to be one of the most important prognostic factors for overall and disease-specific survival in elderly GC patients, along with cancer stage.

SUBMITTER: Choi Y

PROVIDER: S-EPMC8984166 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Publications

Gastric Cancer in Older Patients: A Retrospective Study and Literature Review.

Choi Yonghoon Y Kim Nayoung N Kim Ki Wook KW Jo Hyeong Ho HH Park Jaehyung J Yoon Hyuk H Shin Cheol Min CM Park Young Soo YS Lee Dong Ho DH

Annals of geriatric medicine and research 20220318 1

<h4>Background</h4>With increasing life expectancy, the incidence of gastric cancer (GC) in older adults is increasing. This study analyzed differences in GC characteristics according to age and sex among patients who underwent surgical treatment for GC.<h4>Methods</h4>A total of 2,983 patients diagnosed with gastric adenocarcinoma who underwent surgical treatment at Seoul National University Bundang Hospital between 2003 and 2017 were classified into three groups: I (<65 years, n=1,680), II ...[more]

PMID: 35298880

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Dataset Information

Gastric Cancer in Older Patients: A Retrospective Study and Literature Review.

Background

Methods

Results

Conclusion

Publications

Gastric Cancer in Older Patients: A Retrospective Study and Literature Review.

Similar Datasets

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