Heterogeneity of Starved Yeast Cells in IF₁ Levels Suggests the Role of This Protein in vivo.

ABSTRACT: In mitochondria, a small protein IF₁ suppresses the hydrolytic activity of ATP synthase and presumably prevents excessive ATP hydrolysis under conditions of energy deprivation. In yeast Saccharomyces cerevisiae, IF₁ homologs are encoded by two paralogous genes: INH1 and STF1. INH1 expression is known to aggravate the deleterious effects of mitochondrial DNA (mtDNA) depletion. Surprisingly, no beneficial effects of INH1 and STF1 were documented for yeast so far, and the functions of INH1 and STF1 in wild type cells are unclear. Here, we put forward a hypothesis that INH1 and STF1 bring advantage during the fast start of proliferation after reentry into exponential growth from post-diauxic or stationa

SUBMITTER: Galkina KV 

PROVIDER: S-EPMC8984185 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature