The Botanical Drug PBI-05204, a Supercritical CO₂ Extract of Nerium Oleander, Is Synergistic With Radiotherapy in Models of Human Glioblastoma.

ABSTRACT: Glioblastoma multiforme (GBM) is the most common as well as one of the most malignant types of brain cancer. Despite progress in development of novel therapies for the treatment of GBM, it remains largely incurable with a poor prognosis and a very low life expectancy. Recent studies have shown that oleandrin, a unique cardiac glycoside from Nerium oleander, as well as a defined extract (PBI-05204) that contains this molecule, inhibit growth of human glioblastoma, and modulate glioblastoma patient-derived stem cell-renewal properties. Here we demonstrate that PBI-05204 treatment leads to an increase in vitro in the sensitivity of GBM cells to radiation in which the main mechanisms are the transition from autophagy to apoptosis, enhanced DNA damage and reduced DNA repair after

SUBMITTER: Colapietro A 

PROVIDER: S-EPMC8984197 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature