Altered Brain Activity in Depression of Parkinson's Disease: A Meta-Analysis and Validation Study.

ABSTRACT:

Background

The pathophysiology of depression in Parkinson's disease (PD) is not fully understood. Studies based upon functional MRI (fMRI) showed the alterations in the blood-oxygen-level-dependent (BOLD) fluctuations in multiple brain regions pertaining to depression in PD. However, large variance was observed across previous studies. Therefore, we conducted a meta-analysis to quantitatively evaluate the results in previous publications and completed an independent regions-of-interests (ROIs)-based analysis using our own data to validate the results of the meta-analysis.

Methods

We searched PubMed, Embase, and Web of Science to identify fMRI studies in PD patients with depression. Using signed differential mapping (SDM) method, we performed a voxel-based meta-analysis. Then

SUBMITTER: Su D 

PROVIDER: S-EPMC8984499 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature