The concise synthesis and resolution of planar chiral [2.2]paracyclophane oxazolines by C-H activation.

ABSTRACT: Planar chiral [2.2]paracyclophanes are resolved through the direct C-H arylation of enantiopure oxazolines, providing a convenient route to ligands and chiral materials. Preliminary results show that hydrolysis followed by decarboxylative phosphorylation leads to enantiopure [2.2]paracyclophane derivatives that are otherwise challenging to prepare.

SUBMITTER: Tewari S 

PROVIDER: S-EPMC8984818 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature