Beneficial Effects of Cardiomyopathy-Associated Genetic Variants on Physical Performance: A Hypothesis-Generating Scoping Review.

ABSTRACT:

Background

Genetic variants associated with cardiomyopathies (CMPs) are prevalent in the general population. In young athletes, CMPs account for roughly a quarter of sudden cardiac death, with further unexplained clustering in specific sports. Consequently, most CMPs form a contraindication for competitive sports. We hypothesized that genetic variants might (paradoxically) improve physical performance early in life while impairing cardiac function later in life.

Methods

Systematic PubMed search was done to investigate whether genetic variants in genes associated with CMPs could be related to beneficial performance phenotypes.

Summary

In a limited number of studies (n = 6), 2,860 individuals/subjects with genetic variants were able to outperform those without said vari

SUBMITTER: Verwijs SM 

PROVIDER: S-EPMC8985030 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature