Expression of Oncogenic Molecules in Pediatric Ulcerative Colitis.

ABSTRACT:

Introduction

Long-term disease duration of ulcerative colitis (UC) is known to increase the risk of developing colorectal cancer in adults; however, this association has not been genetically analyzed in children with UC. Herein, we examined the expression of cancer-related genes in the colonic mucosa of pediatric UC patients and their risk of developing colorectal cancer.

Methods

Microarray analysis of cancer-related gene expression was conducted on rectal mucosa biopsy specimens randomly selected from pediatric cases, including 4 active-phase UC cases, 3 remission-phase UC cases, and 3 irritable bowel syndrome control cases. The subject pool was then expanded to 10 active-phase cases, 10 remission-phase cases, and 10 controls, which were analyzed by real-time polymerase cha

SUBMITTER: Arai N 

PROVIDER: S-EPMC8985031 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature