Chemical constituents from Carica papaya Linn. leaves as potential cytotoxic, EGFR^wt and aromatase (CYP19A) inhibitors; a study supported by molecular docking.

ABSTRACT: The phytochemical investigation of the hydromethanolic extract of Carica papaya Linn. leaves (Caricaceae) resulted in the isolation and characterization of ten compounds, namely; carpaine (1), methyl gallate (2), loliolide (3), rutin (4), clitorin (5), kaempferol-3-O-neohesperidoside (6), isoquercetin (7), nicotiflorin (8) and isorhamnetin-3-O-β-d-glucopyranoside (9). The compounds 2, 3, 5-7 and 9 were isolated for the first time from the genus Carica. An in vitro breast cancer cytotoxicity study was evaluated with an MCF-7 cell line using the MTT assay. Methyl gallate and clitorin demonstrated the most potent cytotoxic activities with an IC₅₀ of 1.11 ± 0.06 and 2.47 ± 0.14 μM, respectively. Moreover, methyl gallate and nicotiflorin exhibited p

SUBMITTER: Hamed ANE 

PROVIDER: S-EPMC8985094 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature