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Bakuchiol - a natural meroterpenoid: structure, isolation, synthesis and functionalization approaches.

ABSTRACT: Bakuchiol is an emblematic meroterpene class of natural product extracted from Psoralea corylifolia. It has been reported to possess a broad range of biological and pharmacological properties and is considered as a leading biomolecule. It is highly desirable to devise an efficient approach to access bakuchiol and its chemical biology applications. In this review we provided structural features, isolation methods, various chemical routes and late-stage functionalization (LSF) approaches for bakuchiol and its derivatives. Moreover, this review encompasses the structure-activity relationships (SAR), value-added contributions and future perspectives of bakuchiol.

SUBMITTER: Adarsh Krishna TP

PROVIDER: S-EPMC8985110 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Bakuchiol - a natural meroterpenoid: structure, isolation, synthesis and functionalization approaches.

Adarsh Krishna T P TP Edachery Baldev B Athalathil Sunil S

RSC advances 20220321 14

Bakuchiol is an emblematic meroterpene class of natural product extracted from <i>Psoralea corylifolia</i>. It has been reported to possess a broad range of biological and pharmacological properties and is considered as a leading biomolecule. It is highly desirable to devise an efficient approach to access bakuchiol and its chemical biology applications. In this review we provided structural features, isolation methods, various chemical routes and late-stage functionalization (LSF) approaches fo ...[more]

PMID: 35424800

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