Local and distant cortical responses to single pulse intracranial stimulation in the human brain are differentially modulated by specific stimulation parameters.

ABSTRACT:

Background

Electrical neuromodulation via direct electrical stimulation (DES) is an increasingly common therapy for a wide variety of neuropsychiatric diseases. Unfortunately, therapeutic efficacy is inconsistent, likely due to our limited understanding of the relationship between the massive stimulation parameter space and brain tissue responses.

Objective

To better understand how different parameters induce varied neural responses, we systematically examined single pulse-induced cortico-cortico evoked potentials (CCEP) as a function of stimulation amplitude, duration, brain region, and whether grey or white matter was stimulated.

Methods

We measured voltage peak amplitudes and area under the curve (AUC) of intracranially recorded stimulation responses as a function

SUBMITTER: Paulk AC 

PROVIDER: S-EPMC8985164 | biostudies-literature | 2022 Mar-Apr

REPOSITORIES: biostudies-literature