Biodegradable MoO _x @MB incorporated hydrogel as light-activated dressing for rapid and safe bacteria eradication and wound healing.

ABSTRACT: Wounds infected with drug-resistant bacteria are hard to treat, which remains a serious problem in clinical practice. An innovative strategy for treating wound infections is thus imperative. Herein, we describe the construction of a nanocomposite from biocompatible poly(vinyl alcohol) (PVA)/polyethylene glycol (PEG) hydrogel loaded biodegradable MoO _x nanoparticles (NPs) and photosensitizer methylene blue (MB), denoted as MoO _x @MB-hy. By incorporating MoO _x @MB NPs, the nanocomposite hydrogel can act as a photoactivated wound dressing for near-infrared-II 1064 nm and 660 nm laser synergetic photothermal-photodynamic therapy (PTT-PDT). The key to PTT-induced heat becomes the most controllable release of MB from MoO _x @

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8985166 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature