Targeting selenoprotein H in the nucleolus suppresses tumors and metastases by Isovalerylspiramycin I.

ABSTRACT:

Background

Compared to normal cells, cancer cells exhibit a higher level of oxidative stress, which primes key cellular and metabolic pathways and thereby increases their resilience under oxidative stress. This higher level of oxidative stress also can be exploited to kill tumor cells while leaving normal cells intact. In this study we have found that isovalerylspiramycin I (ISP I), a novel macrolide antibiotic, suppresses cancer cell growth and tumor metastases by targeting the nucleolar protein selenoprotein H (SELH), which plays critical roles in keeping redox homeostasis and genome stability in cancer cells.

Methods

We developed ISP I through genetic recombination and tested the antitumor effects using primary and metastatic cancer models. The drug target was identified

SUBMITTER: Cui J 

PROVIDER: S-EPMC8985259 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature